منابع مشابه
Basement membranes
Basement membranes (BMs) are thin, dense sheets of specialized, self-assembled extracellular matrix that surround most animal tissues (Figure 1, top). The emergence of BMs coincided with the origin of multicellularity in animals, suggesting that they were essential for the formation of tissues. Their sheet-like structure derives from two independent polymeric networks - one of laminin and one o...
متن کاملBasement membranes.
Basement membranes are thin, specialized extracellular matrices surrounding most tissues in all metazoans. The compositions and functions of basement membranes have generally been well conserved throughout the subkingdom. Genetic analyses of basement membrane components in C. elegans have provided insights into their assembly and functions during development. Immuno- or GFP-tagged localization ...
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Slime molds provide a textbook example of self-organization. They live as single cells until food becomes scarce. Then, they broadcast chemical signals that trigger their mass assembly into a fruiting body, with some cells forming a stalk and others turning into spores that cast about in the winds to spread far and wide. Neurons in the developing brain complete their own self-organized waltz, c...
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Mutant phagosomes bite off more than they can chew A kbar et al. reveal that the fl y homologue of a gene mutated in human disease encodes a protein required for phagosome matura-tion and digestion of pathogens. The HOPS complex is a multi-subunit tethering factor that regulates vacuole fusion in budding yeast. Metazoans express two versions of the HOPS subunits Vps16p and Vps33p. Vps16A and Vp...
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ژورنال
عنوان ژورنال: Nature Reviews Molecular Cell Biology
سال: 2014
ISSN: 1471-0072,1471-0080
DOI: 10.1038/nrm3912